Legend 4 Ml Each
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Legend 4 Ml Each
Legend 4 ml Each
Legend hyaluronate Injectable Solution 10 mgml 4 ml vial Legend hyaluronate sodium Injectable Solution is a clear colorless solution of low viscosity. Legend Injectable Solution is pyrogen free sterile and does not contain a preservative. It is administered by intravenous or intra-articular injection. Hyaluronic acid the conjugate acid of hyaluronate sodium is extracted from the capsule of Streptococcus spp. and purified resulting in a form which is essentially free of protein and nucleic acids. Legend Injectable Solution is supplied in 2 ml 20 mg and 4 ml 40 mg vials. Each ml contains 10 mg hyaluronate sodium 8.5 mg sodium chloride 0.223 mg sodium phosphate dibasic and 0.04 mg sodium phosphate monobasic. The pH is adjusted to between 6.5 and 8.0 with sodium hydroxide or hydrochloric acid. Chemistry Hyaluronic acid a glycosaminoglycan can exist in the following forms depending upon the chemical environment in which it is found as the acid hyaluronic acid as the sodium salt sodium hyaluronate hyaluronate sodium or as the hyaluronate anion. These terms may be used interchangeably but in all cases reference is made to the glycosaminoglycan composed of repeating subunits of D-glucuronic acid and N-acetyl-D-glucosamine linked together by glycosidic bonds. Since this product originates from a microbial source there is no potential for contamination with dermatan or chondroitin sulfate or any other glycosaminoglycan. Pharmacology Hyaluronic acid is a naturally occurring substance present in connective tissue skin vitreous humour and the umbilical cord in all mammals. High concentrations of hyaluronic acid are also found in the synovial fluid. It also constitutes the major component of the capsule of certain microorganisms. The hyaluronic acid produced by bacteria is of the same structure and configuration as that found in mammals. The actual mechanism of action for hyaluronate sodium in the healing of degenerative joint disease is not completely understood. One major function appears to be the regulation of normal cellular constituents. This effect decreases the impact of exudation enzyme release and subsequent degradation of joint integrity. Additionally hyaluronate sodium exerts an anti-inflammatory action by inhibiting the movement of granulocytes and macrophages. Hyaluronate molecules are long chains which form a filter network interspersed with normal cellular fluids. It is widely accepted that injection directly into the joint pouch enhances the healing of inflamed synovium by restoring lubrication of the joint fluid. This further supplements the visco-elastic properties of normal joint fluid. Contraindications There are no known contraindications for the use of Legend hyaluronate sodium Injectable Solution in horses. Toxicology Legend Injectable Solution was administered to normal horses at one three and five times the recommended intra-articular dosage of 20 mg and the intravenous dosage of 40 mg. T
$98.75
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